.png){kind=icon}
Return
Constant-pattern design method for displacement chromatography
.png){kind=icon}
PRE
AI
DOI：10.1016/j.chroma.2021.462482.png)
.png){kind=icon}
Original request for help.png){kind=icon}
Share.png){kind=icon}
Save
Abstract
En 中文
Displacement chromatography can be used for the purification of many types of chemicals and biochemicals. In the constant-pattern mode, this method can be used for concentrating and separating various mixtures, leading to higher yields and sorbent productivities than elution chromatography. There are, however, no commercial-scale applications of displacement chromatography. One major barrier is the difficulty in specifying the design variables for reaching a constant-pattern state. A second barrier is that productivity is limited when the feed mixture contains a minority component. In this study, a constant pattern design method is developed to overcome the first barrier. Theoretical analyses and strategically chosen combinations of key dimensionless groups are used for reducing the multi-dimensional parameter space into a two-dimensional space. Systematic rate model simulations are used to find a general correlation, which divides the two-dimensional space into a transient region and a constant-pattern region. A predictive design method based on the general correlation is developed to find the designs for achieving required product purities and yields with the highest productivities. The design method was shown to increase significantly the productivities or yields for the separations of three binary mixtures. To overcome the second barrier, a multi-zone displacement chromatography method is presented for dividing the separation tasks in multiple zones. For a specific ternary mixture containing a minority component, the sorbent productivity for a two-zone design was 680 times higher than that of a single-column design. This method can be used for developing efficient displacement chromatography processes for purifying a wide range of complex mixtures. (c) 2021 Elsevier B.V. All rights reserved.
Keywords:
Constant-pattern design method
Constant-pattern isotachic train
Systematic splitting strategy
Multi-zone displacement chromatography
for complex mixtures
AI Summary
Key information extracted from the uploaded paper, including a brief overview, abstract, background, key highlights, visual analysis, and future outlook.
Journal
IF:
4
Papers:
3.2W
Citations:
5.0W
Organization
Cited Papers
Two-zone ligand-assisted displacement chromatography for producing high-purity praseodymium, neodymium, and dysprosium with high yield and high productivity from crude mixtures derived from waste magnets.png)
GREEN CHEMISTRY
GREEN CHEMISTRYIF9.2
PREAI
ShareSaveShareSaveShareSave
ShareSaveApplication of Displacement Chromatography to Online Two-Dimensional Liquid Chromatography Coupled to Tandem Mass Spectrometry Improves Peptide Separation Efficiency and Detectability for the Analysis of Complex ProteomesANALYTICAL CHEMISTRY
OAAI
ANALYTICAL CHEMISTRYIF6.7
OAAIShareSaveShareSave
View more