.png){kind=icon}
.png){kind=icon}
Return
Constitutive Androstane Receptor (CAR) regulates bile acid homeostasis and metabolism during liver regeneration
.png){kind=icon}
OA
AI
W
U
J
S
A
A
A
D
S
DOI：10.1016/j.jcmgh.2026.101858.png)
.png){kind=icon}
.png){kind=icon}
Share.png){kind=icon}
Save
Abstract
En 中文
Constitutive Androstane Receptor (CAR) transcriptionally regulates xenobiotic detoxification, metabolism, and hepatocyte proliferation. While CAR activation promotes regeneration and its loss impairs recovery after extreme hepatectomy (86-90% liver resection), its temporal role during standard liver regeneration following 2/3rd partial hepatectomy (PHx) remains unclear.
Keywords:
nuclear receptor
liver regeneration
proliferation
metabolism
ALT
alanine aminotransferase
AST
aspartate aminotransferase
BA
bile acid
BrdU
5-bromo-2'-deoxyuridine
Bsep
bile salt export pump
CA
cholic acid
CAR
constitutive androstane receptor
CarKO
Car knockout
Ccna2
cyclin A2
Ccnb1/2
cyclin B1/2
Ccnd1
cyclin D1
Ccne1
cyclin e1
Cdk1
cyclin-dependent kinase 1
CDCA
chenodeoxycholic acid
CHR
cholestyramine
c-Myc
myelocytomatosis oncogene
Cyp2b10
cytochrome P450, family 2, subfamily b, member 10
Cyp3a11
cytochrome P450, family 3, subfamily a, member 11
Cyp7a1
cytochrome P450, family 7, subfamily a, member 1
Cyp8b1
cytochrome P450, family 8,subfamily b, member 1, family 27, subfamily a, member 1
DCA
deoxycholic acid
EGFR
epidermal growth factor receptor
FGF15
fibroblast growth factor 15
Foxm1
forkhead box m1
FXR
farnesoid X receptor
GAPDH
glyceraldehyde 3-phosphate dehydrogenase
HPLC
high-performance liquid chromatography
LCA
lithocholic acid
LC-MS
liquid chromatography-mass spectrometry
MCA
muricholic acid
MET
met proto-oncogene
MRM
multiple-reaction monitoring
Mrp2/3/4
multidrug resistance protein 2/3/4
PHx
partial hepatectomy
PXR
pregnane X receptor
Shp
small heterodimer partner
Sult2a1
sulfotransferase family 2A
DHEA
dehydroepiandrosterone, preferring, member 1
TCPOBOP
1,4-Bis-[2-(3,5-dichloropyridyloxy)]benzene
UDCA
ursodeoxycholic acid
WT
wild-type
YAP
Yes-associated protein
36B4
ribosomal protein
large
P0)
AI Summary
Key information extracted from the uploaded paper, including a brief overview, abstract, background, key highlights, visual analysis, and future outlook.
Journal
IF:
7.4
Papers:
1.5K
Citations:
6.8K
Organization
Cited Papers