.png){kind=icon}
.png){kind=icon}
Return
Constructing Tissuelike Complex Structures Using Cell-Laden DNA Hydrogel Bricks
.png){kind=icon}
OA
AI
DOI：10.1021/acsami.7b01604.png)
.png){kind=icon}
.png){kind=icon}
Share.png){kind=icon}
Save
Abstract
En 中文
Tissue engineering has long been a challenge because of the difficulty of addressing the requirements that such an engineered tissue must meet. In this paper, we developed a new brick-to-wall based on unique properties of DNA supramolecular hydrogels to fabricate three-dimensional (3D) tissuelike structures: different cell types are encapsulated in DNA hydrogel bricks which are then combined to build 3D structures. Signal responsiveness of cells through the DNA gels was evaluated and it was discovered that the gel permits cell migration in 3D. The results demonstrated that this technology is convenient, effective and reliable for cell manipulation, and we believe that it will benefit artificial tissue fabrication and future large-scale production.
Keywords:
DNA hydrogel
tissue engineering
cell arrangements
cell migration
self-healing
supramolecular
AI Summary
Key information extracted from the uploaded paper, including a brief overview, abstract, background, key highlights, visual analysis, and future outlook.
Journal
IF:
8.2
Papers:
6.1W
Citations:
38.7W
View more organizations