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Construction of a dual-mode sensing platform for ANS-inserted CoCu-LDH composites and its high-performance detection of dopamine
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DOI：10.1016/j.saa.2026.127789.png)
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Abstract
En 中文
Dopamine (DA), a crucial neurotransmitter, demands precise monitoring due to its implications in neurological disorders. Current single-mode detection strategies often suffer from reliability issues. To address this, we engineered a novel hierarchical nanoarchitecture by co-intercalating the fluorescent molecule 1-naphthylamine8-sulfonate (ANS) and the surfactant sodium 1-octanesulfonate (OS) into cobalt-copper layered double hydroxide (CoCu-LDH), followed by exfoliation into colloidal nanosheets (OS0.2ANS0.8-LDH). This design ingeniously integrates dual detection modalities within a single material. The LDH host provides a confined environment that enhances and stabilizes the fluorescence of ANS, while the Co3+/Co2+ and Cu2+ redox couples create an efficient electrocatalytic center. For fluorescence detection, DA quenches the ANS emission via a synergistic mechanism involving dynamic quenching and an inner filter effect, achieving a high sensitivity with a limit of detection as low as 0.069 & micro;M. For electrochemical detection, the composite-modified electrode exhibits excellent electrocatalytic activity toward DA oxidation with a wide linear range and achieves a low detection limit of 0.093 & micro;M. The sensor demonstrates exceptional selectivity against common interferents and reliable performance in real tap water samples, where the recovery rates for DA were determined to be between 96.8% and 99.6%. This work presents not only a high-performance bifunctional sensing platform but also a generalizable material design strategy for constructing self-validating diagnostic devices.
Keywords:
Fluorescence/electrochemistry sensor
CoCu-LDH
ANS
Dopamine
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4.6
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2.4W
Citations:
5.5W
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