.png){kind=icon}
.png){kind=icon}
Return
Construction of an Integrated Janus PVA/EW Hybrid Membrane via Unidirectional Nanopore Dehydration for Synergistic Periodontal Regeneration
.png){kind=icon}
OA
AI
X
X
H
M
F
H
Y
DOI：10.1002/mame.70243.png)
.png){kind=icon}
.png){kind=icon}
Share.png){kind=icon}
Save
Abstract
En 中文
To address inadequate interlayer integration and insufficient vascularization in guided tissue regeneration (GTR) membranes, this study employs a unidirectional nanopore dehydration technology previously developed by our group to fabricate a polyvinyl alcohol/egg white (PVA/EW) Janus hybrid membrane. Scanning electron microscopy revealed seamless integration between dense (pore diameter: 0.2−2 µm) and porous layers (pore diameter: 10−100 µm) without distinct interfaces. Crucially, EW was enriched in the porous layer (validated by Fourier transform infrared spectroscopy), endowing the membrane with enhanced bioactivity. After tannic acid-assisted biomimetic mineralization, the PVA/EW20-H membrane achieved a tensile stress of 2.38 ± 1.09 MPa and strain of ∼650%, representing about a 4-fold increase in strength compared to non-mineralized counterparts. The membrane exhibited selective permeability, allowing approximately 40% cumulative release of 4 kDa FITC-dextran over 50 h while effectively blocking L929 fibroblast infiltration. In vitro, the membranes promoted HUVEC migration, suggesting a potential to support early angiogenic processes, and enhanced osteogenesis in MC3T3-E1 cells, as assessed by alkaline phosphatase/alizarin red S staining and qRT-PCR. Thus, our work represents a facile, green, and biocompatible PVA/EW membrane, offering a promising candidate for periodontal regeneration that warrants further investigation.
Keywords:
Janus membrane
periodontal regeneration
Unidirectional nanopore dehydration
AI Summary
Key information extracted from the uploaded paper, including a brief overview, abstract, background, key highlights, visual analysis, and future outlook.
Journal
IF:
4.6
Papers:
4.1K
Citations:
9.5K
Organization
Cited Papers