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Context-specific Polycomb mechanisms in development
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DOI：10.1038/s41576-022-00499-0.png)
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Abstract
En 中文
Polycomb group (PcG) proteins are crucial chromatin regulators that maintain repression of lineage-inappropriate genes and are therefore required for stable cell fate. Recent advances show that PcG proteins form distinct multi-protein complexes in various cellular environments, such as in early development, adult tissue maintenance and cancer. This surprising compositional diversity provides the basis for mechanistic diversity. Understanding this complexity deepens and refines the principles of PcG complex recruitment, target-gene repression and inheritance of memory. We review how the core molecular mechanism of Polycomb complexes operates in diverse developmental settings and propose that context-dependent changes in composition and mechanism are essential for proper epigenetic regulation in development. In this Review, Kim and Kingston discuss the compositional and mechanistic diversity of Polycomb repressive complexes (PRCs) and how their context-dependent formation may be required for proper epigenetic regulation in development.
Keywords:
REPRESSIVE COMPLEX 2
HISTONE METHYLTRANSFERASE ACTIVITY
RECRUITING PRC1 COMPLEX
GROUP PROTEINS RING1A/B
EMBRYONIC STEM-CELLS
EXTRA-SEX-COMBS
H3 LYSINE 27
H2A UBIQUITYLATION
CPG ISLANDS
CONSTITUTIVE HETEROCHROMATIN