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Continuous nanoprecipitation of poly(D,L-Lactide) in a rotor-stator spinning disk reactor
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DOI：10.1016/j.cep.2025.110572.png)
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Abstract
En 中文
• A rotor-stator spinning disk reactor produced polymeric particles as small as 58 nm. • Particle dispersity ranged from 0.10 to 0.22. • Polymer concentration and disk rotation determined particle size. • Nanoparticles can be produced at a rate of 0.8 kg/day. • Drug loading of ibuprofen in polylactic acid nanoparticles peaked at 6 %.
Keywords:
Rotor-stator spinning disk reactor
poly(D,L-Lactide)
Nanoprecipitation
Nanoparticles
Drug loading
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