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Control of REM sleep and wakefulness by lateral periaqueductal gray glutamatergic neurons
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DOI：10.1016/j.celrep.2026.117821.png)
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Abstract
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• LPAG glutamatergic neurons are activated during REM sleep and wakefulness • Inhibition of these neurons decreases REM sleep; their activation promotes wakefulness • LPAG glutamatergic neurons regulate REM sleep via the projection to the SLD • LPAG glutamatergic neurons induce wakefulness through the LC and GiV pathways
Keywords:
lateral periaqueductal gray
locus coeruleus
rapid eye movement sleep
ventral gigantocellular reticular nucleus
wakefulness
CP: neuroscience
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