Controlling colloidal flow through a microfluidic Y-junction

doi:10.1038/s42005-025-02094-1

Controlling colloidal flow through a microfluidic Y-junction

2025-04-16

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Fabian Jan Schwarzendahl

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Carolina Rodríguez-Gallo

DOI：10.1038/s42005-025-02094-1

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Microscopic particles flowing through narrow channels may accumulate near bifurcation points provoking flow reduction, clogging and ultimately chip breakage in a microfluidic device. Here we show that the full flow behavior of colloidal particles through a microfluidic Y-junction can be controlled by tuning the pair interactions and the degree of confinement. By combining experiments with numerical simulations, we investigate the dynamic states emerging when magnetizable colloids flow through a symmetric Y-junction such that a single particle can pass through both gates with the same probability. We show that clogging, induced by the inevitable presence of a stagnation point, can be avoided by repulsive interactions. Moreover we tune the pair interactions to steer branching into the two channels: attractive particles are flowing through the same gate, while repulsive colloids alternate between the two gates. Even details of the particle assembly such as buckling at the exit gate are tunable by the interactions and the channel geometry.

Keywords:

ESCHERICHIA-COLI

BLOOD

TRANSPORT

DYNAMICS

CELLS

Controlling colloidal flow through a microfluidic Y-junction

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