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Coordinating gene expression during the cell cycle
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DOI：10.1016/j.tibs.2022.06.007.png)
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Abstract
En 中文
Cell cycle-dependent gene transcription is tightly controlled by the retinoblastoma (RB):E2F and DREAM complexes, which repress all cell cycle genes during quiescence. Cyclin-dependent kinase (CDK) phosphorylation of RB and DREAM allows for the expression of two gene sets. The first set of genes, with peak expression in G1/S, is activated by E2F transcription factors (TFs) and is required for DNA synthesis. The second set, with maximum expression during G2/M, is required for mitosis and is coordinated by the MuvB complex, together with B-MYB and Forkhead box M1 (FOXM1). In this review, we summarize the key findings that established the distinct control mechanisms regulating G1/S and G2/M gene expression in mammals and discuss recent advances in the understanding of the temporal control of these genes.
Keywords:
S-M CHECKPOINT
DREAM COMPLEX
TRANSCRIPTION FACTOR
PROTEIN COMPLEX
REPRESS TRANSCRIPTION
MOLECULAR-MECHANISMS
REPLICATION STRESS
TUMOR-SUPPRESSOR
MUVB COMPLEX
B-MYB
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