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Coordination between Differentially Regulated Circadian Clocks Generates Rhythmic Behavior
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DOI：10.1101/cshperspect.a033589.png)
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Abstract
En 中文
Specialized groups of neurons in the brain are key mediators of circadian rhythms, receiving daily environmental cues and communicating those signals to other tissues in the organism for entrainment and to organize circadian physiology. In Drosophila, the circadian clock is housed in seven neuronal clusters, which are defined by their expression of the main circadian proteins, Period, Timeless, Clock, and Cycle. These clusters are distributed across the fly brain and are thereby subject to the respective environments associated with their anatomical locations. While these core components are universally expressed in all neurons of the circadian network, additional regulatory proteins that act on these components are differentially expressed, giving rise to local clocks within the network that nonetheless converge to regulate coherent behavioral rhythms. In this review, we describe the communication between the neurons of the circadian network and the molecular differences within neurons of this network. We focus on differences in protein-expression patterns and discuss how such variation can impart functional differences in each local clock. Finally, we summarize our current understanding of how communication within the circadian network intersects with intracellular biochemical mechanisms to ultimately specify behavioral rhythms. We propose that additional efforts are required to identify regulatory mechanisms within each neuronal cluster to understand the molecular basis of circadian behavior.
Keywords:
DROSOPHILA PERIOD PROTEIN
LOCOMOTOR-ACTIVITY RHYTHM
VENTRAL LATERAL NEURONS
ION-TRANSPORT PEPTIDE
SHORT NEUROPEPTIDE F
MESSENGER-RNA LEVELS
CASEIN KINASE-I
PACEMAKER NEURONS
GENE-EXPRESSION
COMPOUND EYES
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