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Copper-Catalyzed Enantioselective Protoboration of α-Substituted tert-Butyl Acrylates
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DOI：10.1021/acs.joc.6c00629.png)
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Abstract
En 中文
An efficient copper-catalyzed asymmetric protoboration of alpha-substituted tert-butyl acrylates has been developed, providing beta-borylated propionate products in good yields and high enantioselectivities. The tert-butyl ester group is essential for achieving high enantioselectivity. This methodology has been successfully scaled up to the one-gram level and applied to diverse stereoselective derivatizations.
Keywords:
ALPHA,BETA-UNSATURATED ESTERS
ASYMMETRIC HYDROBORATION
BETA-BORATION
BORYLATION
REGIO
TRANSFORMATIONS
AMIDES
Journal
IF:
3.6
Papers:
5.4W
Citations:
8.8W
Organization
Cited Papers