.png){kind=icon}
.png){kind=icon}
Return
Copper-Induced Nephropathy: Clinical Characterization of 36 Cases and Comprehensive Literature Review
.png){kind=icon}
PRE
AI
DOI：10.1007/s12011-025-04869-7.png)
.png){kind=icon}
Original request for help.png){kind=icon}
Share.png){kind=icon}
Save
Abstract
En 中文
The etiology of chronic kidney disease (CKD) is complex, with environmental copper exposure emerging as a non-traditional risk factor whose nephrotoxic mechanisms and impacts require in-depth investigation. This study conducted a retrospective analysis of 36 patients with abnormally elevated urinary copper levels, evaluating their clinical manifestations, biochemical indicators, and responses following copper chelation therapy, along with a literature review to explore the relationship between copper levels and renal injury. The results demonstrated a significant correlation between urinary copper content and the severity of renal dysfunction (P < 0.001). After treatment, improvements were observed in renal function (BUA P = 0.046), liver function (ALT P = 0.013), and anemia indicators (HGB P = 0.034). These findings indicate that abnormal urinary copper is a risk factor for kidney injury.
Keywords:
Nephrotic syndrome
Abnormal urinary copper
Gene-environment interaction mechanism
Copper chelation therapy
Journal
IF:
3.6
Papers:
8.8K
Citations:
1.8W
Organization
View more organizations