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Correlations between ghrelin gene polymorphisms, cognitive function, and activities of daily living among elderly patients with Alzheimer's disease
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DOI：10.1080/03014460.2025.2507048.png)
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Abstract
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Background Single nucleotide polymorphisms (SNPs) of ghrelin gene are associated with cognitive function while ghrelin is associated with Alzheimer's disease (AD). Aim To determine the relationship between ghrelin SNPs, cognitive function, and activities of daily living (ADLs) in elderly AD patients. Subjects and methodsThis study included 100 elderly AD patients as the AD group, and 72 elderly healthy patients as the control group. Pearson's correlation analysis was performed. Results The frequency of the A allele at rs55821288 was significantly higher in the AD group than the control group (p < 0.05). Similarly, the frequency of the AA genotype at rs55821288 was higher in the AD group than the control group (p < 0.05). The MMSE, QOL-AD, and ADLs scores were lower in the AD group than the control group (p < 0.05). Pearson's correlation analysis revealed that the A allele at rs55821288 was inversely correlated with the MMSE, QOL-AD, and ADLs scores (p < 0.05). The distribution of the AA genotype at the rs55821288 locus had a negative linear correlation with the MMSE, QOL-AD, and ADLs scores (p < 0.05). Conclusions Ghrelin allele A and genotype AA are closely associated with cognitive function and ADLs among elderly AD patients.
Keywords:
Ghrelin gene
single nucleotide polymorphism (SNP)
activities of daily living (ADLs)
cognitive function
correlation analysis
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