.png){kind=icon}
.png){kind=icon}
Return
Cortical Feedback Regulates Feedforward Retinogeniculate Refinement
.png){kind=icon}
OA
AI
DOI：10.1016/j.neuron.2016.07.040.png)
.png){kind=icon}
.png){kind=icon}
Share.png){kind=icon}
Save
Abstract
En 中文
According to the prevailing view of neural development, sensory pathways develop sequentially in a feedforward manner, whereby each local microcircuit refines and stabilizes before directing the wiring of its downstream target. In the visual system, retinal circuits are thought to mature first and direct refinement in the thalamus, after which cortical circuits refine with experience-dependent plasticity. In contrast, we now show that feedback from cortex to thalamus critically regulates refinement of the retinogeniculate projection during a discrete window in development, beginning at postnatal day 20 in mice. Disrupting cortical activity during this window, pharmacologically or chemogenetically, increases the number of retinal ganglion cells innervating each thalamic relay neuron. These results suggest that primary sensory structures develop through the concurrent and interdependent remodeling of subcortical and cortical circuits in response to sensory experience, rather than through a simple feedforward process. Our findings also highlight an unexpected function for the corticothalamic projection.
Keywords:
LATERAL GENICULATE-NUCLEUS
EXPERIENCE-DEPENDENT PLASTICITY
PROTEIN-COUPLED RECEPTORS
PRIMARY VISUAL-CORTEX
LAYER 6
CORTICOGENICULATE INNERVATION
SENSORY EXPERIENCE
TOPOGRAPHIC MAPS
RELAY CELLS
SYNAPSE
AI Summary
Key information extracted from the uploaded paper, including a brief overview, abstract, background, key highlights, visual analysis, and future outlook.