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Cosmc loss induces truncated O-glycosylation and accelerates Kras-driven pancreatic carcinogenesis
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DOI：10.1016/j.neo.2026.101347.png)
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Abstract
En 中文
• Tn antigen is frequently expressed in human PDAC and associates with tumor stage. • Cosmc loss accelerates early Kras-driven pancreatic neoplastic progression. • Cosmc-deficient tumors show increased fibrosis, proliferation, and altered mucin-associated glycosylation. • Cosmc loss induces a robust Tn-like glycoprotein phenotype in pancreatic tumors. • Glycoproteomic profiling links Cosmc loss to extracellular matrix and stromal remodeling.
Keywords:
Pancreatic cancer
PDAC
Cosmc
O-glycosylation
Tn antigen
Kras
Mouse model
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