Coupled quartz crystal microbalance – Surface enhanced Raman scattering strategy for the design and testing of aptasensors for small analytes

doi:10.1016/j.snb.2025.138154

Coupled quartz crystal microbalance – Surface enhanced Raman scattering strategy for the design and testing of aptasensors for small analytes

2025-07-08

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Marc Lamy de la Chapelle *

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Souhir Boujday *

DOI：10.1016/j.snb.2025.138154

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• Nanopatterned gold-coated quartz crystal sensors were elaborated by EBL. • A 23mer DNA aptamer was chemisorbed onto the gold surface. • QCM-D and SERS provided the sensing layer’s molecular composition and the mass uptake. • Binding of streptomycin was concomitantly monitored by QCM-D and SERS. • Dissociation constant was deduced from frequency shifts recorded upon streptomycin binding.

Coupled quartz crystal microbalance – Surface enhanced Raman scattering strategy for the design and testing of aptasensors for small analytes

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