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Coxsackievirus B infection invokes unique cell-type-specific responses in primary human pancreatic islets
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DOI：10.1016/j.celrep.2025.116211.png)
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Abstract
En 中文
• CVB3 infects all islet cell types, triggering distinct cell-specific responses • Ductal cells, not β cells, show the strongest interferon- and HLA-associated responses • CVB3 disrupts mitochondrial function in islet cells, particularly in β and α cells • MIR7-3HG knockdown lowers CVB3 levels and apoptosis and alters autophagy in infected islets
Keywords:
coxsackievirus B
enterovirus
cadaveric pancreatic islets
type 1 diabetes
MIR7-3HG
viral infection
single-cell RNA sequencing
transcriptional signatures
human pluripotent stem cells
CP: Metabolism
CP: Microbiology
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