.png){kind=icon}
Return
CREB and memory
.png){kind=icon}
PRE
AI
DOI：10.1146/annurev.neuro.21.1.127.png)
.png){kind=icon}
Original request for help.png){kind=icon}
Share.png){kind=icon}
Save
Abstract
En 中文
The cAMP responsive element binding protein (CREB) is a nuclear protein that modulates the transcription of genes with cAMP responsive elements in their promoters. Increases in the concentration of either calcium or cAMP can trigger the phosphorylation and activation of CREB. This transcription factor is a component of intracellular signaling events that regulate a wide range of biological functions, from spermatogenesis to circadian rhythms and memory. Here we review the key features of CREB-dependent transcription, as well as the involvement of CREB in memory formation. Evidence from Aplysia, Drosophila, mice, and rats shows that CREB-dependent transcription is required for the cellular events underlying long-term but not short-term memory. While the work in Aplysia and Drosophila only involved CREB function in very simple forms of conditioning, genetic and pharmacological studies in mice and rats demonstrate that CREB is required for a variety of complex forms of memory, including spatial and social learning, thus indicating that CREB may be a universal modulator of processes required for memory formation.
Keywords:
transcription
learning
gene targeting
long-term potentiation
mutants
Journal
IF:
13.2
Papers:
930
Citations:
1.3W
Organization
No organization information available
Cited Papers
ShareSaveModular Segregation of Functional Cell Classes Within the Postcentral Somatosensory Cortex of Monkeys.png)
Science
ScienceIF0
PREAI
ShareSaveShareSaveShareSave
Influence of bodily harm on neural correlates of semantic and moral decision-makingNeuroImage
NeuroImageIF0
PREAI
ShareSaveShareSaveShareSaveShareSave
View more