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credsubs: Multiplicity-Adjusted Subset Identification

delete2020-01-01
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OA
AI
P
Patrick Schnell *
M
Mark Fiecas
B
Bradley P. Carlin
DOI:10.18637/jss.v094.i07delete
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Abstract

Abstract

En 中文
Subset identification methods are used to select the subset of a covariate space over which the conditional distribution of a response has certain properties - for example, identifying types of patients whose conditional treatment effect is positive. An often critical requirement of subset identification methods is multiplicity control, by which the family-wise Type I error rate is controlled, rather than the Type I error rate of each covariate-determined hypothesis separately. The credible subset (or credible subgroup) method provides a multiplicity-controlled estimate of the target subset in the form of two bounding subsets: one which entirely contains the target subset, and one which is entirely contained by it. We introduce a new R package, credsubs, which constructs credible subset estimates using a sample from the joint posterior distribution of any regression model, a description of the covariate space, and a function mapping the parameters and covariates to the subset criterion. We demonstrate parametric and nonparametric applications of the package to a clinical trial dataset and a neuroimaging dataset, respectively.
Keywords:
credible subgroups
multiple hypothesis testing
R
subset identification
subgroup analysis

Journal

Journal of Statistical Software cover
Journal of Statistical Software
IF:
8.1
Papers:
622
Citations:
4.6W

Organization

U
University System of Ohio
Scholars:
15.4W
Papers: 13.0W
Citations: 200
O
Ohio State University
Scholars:
4.1W
Papers: 3.2W
Citations: 80