CRISPR-Cas9-producing probiotic bacteria for editing NOX2/gp91phox and treating inflammatory bowel disease

2026-07-24

章

章春芳 (Chen Zhang)

Tianyu Li

Huoye Hao

Gang Wang

Yuanjun Zhang

Yue Huang

Lili Chen

Jin Wang

Xiang-Jiao Yang

Xiuli Bi *

DOI：10.1016/j.xcrm.2026.102940

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Abstract

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• EcN-RNP hydrogel downregulates NOX2 via genome editing to lower ROS • EcN-RNP hydrogel boosts antioxidant capacity and glutathione to alleviate colitis • CRISPR-Cas9-expressing EcN withstands harsh gastrointestinal environments • Synthetic inducible promoter achieves controllable CRISPR-Cas9 expression

Keywords:

inflammatory bowel disease

reactive oxygen species

NOX2

probiotic bacteria

hydrogel

CRISPR-Cas9

genome editing

CRISPR-Cas9-producing probiotic bacteria for editing NOX2/gp91phox and treating inflammatory bowel disease

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