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Crosslinkable/functionalizable poly(2-oxazoline)based micelles
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DOI：10.1016/j.eurpolymj.2019.109305.png)
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Abstract
En 中文
Considering the pseudo-livingness of the cationic ring-opening polymerization of various 2-oxazoline monomers, micelles formed by amphiphilic diblock copoly(2-oxazoline)s are potential candidates for drug delivery. Copoly (2-oxazoline)s of the composition poly(2-ethyl-2-oxazoline)(100-n)-block-poly(2-dec-9'-enyl-2-oxazoline)(n) (n = 5, 10, 15) were found to form micelles in aqueous solution. The hydrophobic cores of these non-spherical micelles could be crosslinked by the thiol-ene reaction with glycol dimercapto acetate, the ester bonds of which can be cleaved by esterases. While the hydrodynamic radii of the non-crosslinked micelles increased if the hydrophobic block of poly(2-dec-9'-enyl-2-oxazoline) grew larger, the opposite trend could be observed for the crosslinked micelles. In the course of an oil uptake study, the hydrodynamic radii of the crosslinked as well as non-crosslinked micelles increased. In oil-filled micelles of poly(2-ethyl-2-oxazoline)(100-n)-block-poly(2-dec-9'-enyl-2-oxazoline)(n) (n = 5, 10, 15), the hydrodynamic radii of the non-crosslinked micelles were significantly larger in comparison with the crosslinked ones in case of n = 5 and 10, while the hydrodynamic radii of non-crosslinked and crosslinked micelles were of the same range in case of n = 15. The changes of diameter in micelles with polar molecules such as Zidovudine covalently attached to the hydrophobic core support the proposed antagonism of the inclusion of non-polar/polar molecules into the micelles' cores and the degree of crosslinking.
Keywords:
Block copoly(2-oxazoline)s
Critical micellar concentration
Thiol-ene click reaction
Crosslinked micelles
Dynamic light scattering
Worm-shaped micelles
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