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Crystal structure of calcium carbonate coating modulates degradation and bone formation of biodegradable magnesium
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DOI：10.1016/j.actbio.2026.08.009.png)
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Abstract
En 中文
Surface coatings on biodegradable Mg alloys have been extensively explored to inhibit the corrosion of Mg substrate and to promote the bone formation. However, the self-degradation of the coating is rarely seriously considered when it is used to modulate the corrosion of Mg substrate and the osteogenic activity. Based on our previously developed robust CaCO3 coating, considering the stability of different CaCO3 crystalline, the current study evaluates how the crystal structure of CaCO3 coating affects its protection ability to Mg substrate and the corresponding biological response of osteoblasts. To this end, different CaCO3 coatings, calcite coating (C-coating), vaterite coating (V-coating), aragonite coating (A-coating) and mixture coating (C+V+A-coating), are fabricated on pure Mg respectively, for in vitro corrosion performance and osteoblast response as well as in vivo self-degradation of the coatings and their bio-safety. It revealed the most prominent protection ability of plate-like aggregated V-coating to Mg substrate, decreasing in the order of V-coating > C+V+A-coating > C-coating > A-coating. The anti-corrosion ability of the coatings seemly correlates with the compactness and the self-degradation ability of the coating, surprisingly differing with the thermodynamic stability of CaCO3 polymorphs. Correspondingly, V-coating, C-coating and C+V+A-coating exhibited higher cytocompatibility and fortified osteogenic ability for MC3T3-E1 cells due to the hospitable surrounding ion environment and the desired surface features. Noteworthily, the structural reorganization of the coatings into Ca-P products on the surface also contributes to their exceptional osteogenic performance, which is more significant for V-coating, followed by C-coating. The findings of this work suggest that the coating structure could be one of the vital indicators for its corrosion protection ability and the bone regeneration promotion ability of Mg implants, strengthening the underlying functional mechanisms for CaCO3-based coating on biomaterials.
Keywords:
Biodegradable Mg
Calcium carbonate
Corrosion
Osteogenic activity
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9.6
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6.5W
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