Crystalline silica exposure of genetically diverse mice exacerbates subclinical autoimmunity into systemic autoimmune disease phenotypes including inflammatory arthritis in female mice

2026-07-23

PRE

Lisa Janssen

Caroline de Ocampo

Dwight H. Kono

Peter Hoet

K. Michael Pollard *

Jessica M. Mayeux *

DOI：10.1016/j.jaut.2026.103599

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• Naïve CC RI strains exhibit a spectrum of subclinical autoimmune profiles. • Pre-existing subclinical autoimmunity influences severity of c-silica-induced autoimmunity. • C-silica exposure leads to strain-selective development of autoimmune diseases. • Pulmonary exposure to c-silica leads to multiple autoimmune disease phenotypes.

Crystalline silica exposure of genetically diverse mice exacerbates subclinical autoimmunity into systemic autoimmune disease phenotypes including inflammatory arthritis in female mice

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