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Curcumin alleviates cold stress-induced myocardial injury by regulating macrophage polarization through the STUB1/STAT1–STAT6–KLF4 signaling axis
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DOI：10.1016/j.intimp.2026.117045.png)
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Abstract
En 中文
• Cold stress skews cardiac macrophages toward a pro-inflammatory phenotype. • Curcumin attenuates cold stress-induced cardiac dysfunction and injury. • Cold mimicry enhances STUB1-associated STAT1 K48 ubiquitination. • Curcumin restores STAT6-KLF4 reparative macrophage signaling. • Macrophage KLF4 is required for curcumin-mediated cardioprotection.
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