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Curcumin-based benzothiazepane analogues exhibit selective anti-cancer activity in HCT-116 cells via precipitated particle formation and internalisation

delete2025-12-19
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OA
AI
J
Julie De Munck
C
Charlotte Grootaert
K
Katarina Magdalenic
D
Derya Deveci
Y
Yannick Gansemans
F
Filip Van Nieuwerburgh
N
Nico Boon
A
Andre Skirtach
A
Andreja Rajkovic
M
Matthias D’hooghe
J
John Van Camp *
DOI：10.1016/j.biopha.2025.118926delete
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Abstract

Abstract

En 中文
• Two analogues (AT007 and AT096) show higher anti-cancer selectivity than curcumin. • HCT-116 (cancer) cells show acute toxicity; IPEC-J2 (non-cancer) survive longer. • Cytotoxicity correlates with compound aggregation into particles in the medium. • Particle formation is influenced by structure, concentration, medium, and time. • Both cell types internalise the particles but show distinct cellular responses.
Keywords:
Colon cancer
Curcumin
Analogues
Particles
Cellular uptake
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Key information extracted from the uploaded paper, including a brief overview, abstract, background, key highlights, visual analysis, and future outlook.

Journal

B
Biomedicine and Pharmacotherapy
IF:
7.5
Papers:
1.6W
Citations:
8.2W

Organization

S
sartorius netherlands b.v.
Scholars:
1
Papers: 1
Citations: 0
G
Ghent University
Scholars:
5.2W
Papers: 4.5W
Citations: 5.5W
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