CXCL12/CXCR4 axis as a modulator of neurotransmission in depression: a neuroimmune perspective

Kinga Grzybowska

doi:10.1016/j.neubiorev.2026.106717

CXCL12/CXCR4 axis as a modulator of neurotransmission in depression: a neuroimmune perspective

2026-04-30

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K

Kinga Grzybowska *

P

Piotr Czarny

Ł

Łukasz Kołodziej

P

Paulina Wigner

J

Janusz Szemraj

P

Piotr Gałecki

K

Kuan-Pin Su

T

Tomasz Śliwiński

DOI：10.1016/j.neubiorev.2026.106717

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Abstract

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• CXCL12/CXCR4 axis has twofold effects on depression – neuroprotective or neurotoxic • CXCL12/CXCR4 restores synaptic balance by influence on neurotransmitters • CXCL12/CXCR4 axis can be a new promising therapeutic strategies for depression

Keywords:

CXCL12/CXCR4 axis

depression

neurotransmission

neuroimmune perspective

synaptic balance

CXCL12/CXCR4 axis as a modulator of neurotransmission in depression: a neuroimmune perspective

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