.png){kind=icon}
.png){kind=icon}
Return
CYP2C19-mediated metabolic activation and OAT3/P-gp-associated transport contribute to Dioscorea bulbifera L.-induced hepatotoxicity
.png){kind=icon}
PRE
AI
Y
邓
Z
Y
D
S
J
DOI：10.1016/j.jep.2026.122272.png)
.png){kind=icon}
Original request for help.png){kind=icon}
Share.png){kind=icon}
Save
Abstract
En 中文
• 8-epidiosbulbin E acetate is a key toxic component of Dioscorea bulbifera L. and causes significant liver damage. • Cytochrome P450 2C19 is the primary enzyme that efficiently drives the metabolic activation of 8-epidiosbulbin E acetate. • 8-epidiosbulbin E acetate is taken up by the liver via organic anion transporter 3 and expelled via P-glycoprotein. • Inhibiting cytochrome P450 2C19 or organic anion transporter 3 reduces liver damage caused by 8-epidiosbulbin E acetate and Dioscorea bulbifera L.
Journal
IF:
5.4
Papers:
2.6K
Citations:
6.2W
Organization
Cited Papers