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Cysteine metabolism dysregulation promotes ferroptosis in osteoarthritis: Insights from multi-species bioinformatics and experimental validation
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DOI：10.1016/j.jot.2026.101174.png)
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Abstract
En 中文
Osteoarthritis (OA) was traditionally viewed as a mechanically driven disorder. However, emerging evidence implicated metabolic dysregulation in its pathogenesis. This study investigated the novel interaction among cysteine metabolism, ferroptosis, and OA progression, while evaluating the therapeutic efficacy of L-cysteine supplementation.
Keywords:
Chondrocyte
Cysteine metabolism
Ferroptosis
Multi-omics
Osteoarthritis
Oxidative stress
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