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Cytokine Conversations: Fibroblasts Shape Macrophage Identity to Enhance Collagen Clearance
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DOI：10.1016/j.matbio.2026.102010.png)
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Abstract
En 中文
• Fibroblasts drive macrophage differentiation toward a collagen-clearing phenotype • Fibroblasts secrete IL-6 to induce MR/CD206–mediated collagen uptake by macrophages • MR/CD206 is rate-limiting for collagen degradation by macrophages in in vivo models • Novel depleter strain reveals fibroblast impact on macrophage phenotype in mice
Keywords:
Fibroblast-macrophage crosstalk
Mannose receptor
Interleukin-6
Extracellular matrix degradation
collagen endocytosis
Macrophage phenotype
AF
Alexa Flour
BME
basement membrane extract
BMDC
bone marrow-derived progenitor cells
CM
conditioned media
DTR
diphtheria toxin receptor
ECM
extracellular matrix
FAP
fibroblast activation protein
IL-4Rα
IL-4 receptor alpha
MFI
mean fluorescence intensity
MMP
matrix metalloproteinases
MR
mannose receptor
TSP
thrombospondin
uPARAP
urokinase plasminogen activator receptor-associated protein
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