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d-serine as a metabolic immune checkpoint in the tumour microenvironment

delete2026-07-31
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OA
AI
K
Kai Tsugaru
S
S Suzuki
K
Kentaro Miyamoto
K
Kazuhiro Murakami
A
Akihiko Chida
C
C. Kato
N
Naoto Fukasawa
A
Arina Shigehara
M
Mai Hasegawa
Y
Yusuke Yoshimatsu
J
Jumpei Sasabe
M
Masashi Mita
N
Nick Barker
Y
Yosuke Harada
Y
Yasutaka Sukawa
T
Toshiaki Teratani
N
Nobuhiro Nakamoto
H
Hirofumi Kawakubo
K
Kaoru Takabayashi
M
Motohiko Kato
DOI：10.1016/j.ebiom.2026.106402delete
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Abstract

Abstract

En 中文
d-amino acids (D-AAs), the enantiomers of proteinogenic l-amino acids, are detectable in mammals, yet their biological roles in cancer immunity remain largely unexplored. Whether specific D-AAs modulate tumour progression or influence responsiveness to immunotherapy in gastrointestinal cancer is unknown. We aimed to determine how D-AAs, particularly d-serine (D-ser), shape the tumour immune microenvironment and affect clinical outcomes in gastrointestinal cancers.
Keywords:
d-serine
d
Macrophages
CD8+ T cells
Gastric cancer
Metabolite
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EBioMedicine cover
EBioMedicine
IF:
10.8
Papers:
6.4K
Citations:
3.2W

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