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Darolutamide: First Approval
DOI:10.1007/s40265-019-01212-y.png)
Abstract
En 中文
Darolutamide (NUBEQA (TM)) is a structurally distinct non-steroidal androgen receptor antagonist being developed by Orion and Bayer as a treatment for prostate cancer. Based on positive results in the phase III ARAMIS trial, darolutamide was recently approved in the USA for the treatment of men with non-metastatic castration-resistant prostate cancer. This article summarizes the milestones in the development of darolutamide leading to this first approval.
Keywords:
ODM-201
SAFETY
ARADES
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14.4
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8.4K
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2.3W
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Cited Papers
Pharmacokinetics, Antitumor Activity, and Safety of ODM-201 in Patients with Chemotherapy-naive Metastatic Castration-resistant Prostate Cancer: An Open-label Phase 1 Study
EUROPEAN UROLOGY
IF25.2
Darolutamide is a potent androgen receptor antagonist with strong efficacy in prostate cancer models
Structure and composition of the neutral upper atmosphere of Mars from the MAVEN NGIMS investigation
Discovery of ODM-201, a new-generation androgen receptor inhibitor targeting resistance mechanisms to androgen signaling-directed prostate cancer therapies
SCIENTIFIC REPORTS
IF3.9

