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Data-driven copper catalysis enables stereoselective fluorocyclopropanation
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DOI：10.1016/j.chempr.2025.102922.png)
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Abstract
En 中文
• Data-driven Cu catalysis achieves up to 99% ee and 75:1 dr in fluorocyclopropanation • Mechanistic carbene descriptors improve model generalization and prediction • Protocol scales from nanomole screens to gram-scale bioactive targets
Keywords:
fluorocyclopropanation
copper catalysis
stereoselective synthesis
data-driven methodology
carbene descriptors
Journal
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