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Data-driven tools for the optimization of a pharmaceutical process through its knowledge-driven model
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AI
DOI：10.1002/aic.17925.png)
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Abstract
En 中文
The use of computationally demanding knowledge-driven models to optimize a process might encounter substantial numerical challenges. Because a model is an abstraction and approximation of the process, calculating the exact model optimum might not be necessary because its industrial implementation is bound to be an approximate one. Here we are exploring an alternative optimization route through a surrogate model. Because one of the decision variables affecting the optimization is time-varying, the Design of Dynamic Experiments is used to estimate the surrogate model. The process considered here is a freeze-drying process widely used in the pharmaceutical industry. The model used is a stochastic model describing the process in great detail. It is shown that the proposed data-driven route calculates the optimum in about 8 h, as opposed to 22 h for the knowledge-driven model, while sacrificing only < 15% in the computed value of the process performance.
Keywords:
batch process
data-driven modeling
freeze-drying process
optimization
pharmaceuticals
Journal
IF:
4
Papers:
1.1W
Citations:
2.9W