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Deciphering CD8+ T cell exhaustion in human cancers through single-cell and spatial transcriptomics

delete2026-07-28
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PRE
AI
Z
Zixuan Gou
X
Xiao-Jun Huang
X
Xiang‐Yu Zhao *
DOI：10.1016/j.canlet.2026.218767delete
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Abstract

Abstract

En 中文
• Exhausted CD8+T cells (Tex) restrain effective antitumor immunity. • ScRNA-seq and spatial transcriptomics decipher the heterogeneity of Tex. • Tex are associated with the therapeutic efficacy of immune checkpoint blockade. • High-resolution omics advance Tex-targeted immunotherapies.

Journal

Cancer Letters cover
Cancer Letters
IF:
10.1
Papers:
1.7W
Citations:
4.3W

Organization

No organization information available
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