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Deciphering melanoma brain metastases: Role of cellular plasticity and metastatic origin
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DOI：10.1016/j.bioadv.2026.214983.png)
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Abstract
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• Brain-mimetic hydrogels reproduced nonlinear and viscoelastic mechanical features characteristic of brain tissue. • Melanoma cell behavior was dependent on plasticity states (MITFhigh/AXLhigh) and metastatic origin. • Decreasing matrix stiffness promoted proliferation and cluster formation in a cell state–dependent manner. • Hyaluronic acid emerged as a key regulator of melanoma cell spreading in brain-like microenvironments. • Brain-derived melanoma cells exhibited enhanced spreading and adaptation to biomimetic extracellular matrices.
Keywords:
Melanoma
3D cell culture
Mouse brain
Plasticity
Metastatic origin
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