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Deciphering the Impact of Protein Corona on Biological Fate of Nanomedicine-Loaded Microneedles
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DOI：10.2174/0113892002459335260311061441.png)
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Abstract
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Due to adsorption of proteins, abundant protein molecules quickly bind to the nanoparticles' (NPs) surface when they enter the bloodstream, forming a protein corona. The protein corona leads to rapid clearance of NPs, thereby impeding efficient drug delivery. Notably, microneedles (MNs) can reduce protein corona formation by altering the route of drug entry and confining the drug within the local tissue microenvironment. This article outlines the relationship between drug-loaded MNs and the protein corona and proposes strategies to suppress its formation. Furthermore, it underscores that the synergy between microneedles and stealth nanocarriers can minimize the detrimental effects associated with protein corona formation.
Keywords:
Microneedles
Protein corona
dermal interstitial fluid
stealthy effect
bloodstream
nanomedicine
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