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Deciphering the RSPO3-NFATC1 Switch in the Bone-Cartilage Paradox: Genetic Liability to Osteoporosis Protects Against Osteoarthritis by Modulating Subchondral Bone Compliance

delete2026-05-30
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PRE
AI
L
Lei Peng *
J
Jinliang Wei
H
Haoran Yang
J
Jian Qin
Q
Qingchu Li *
DOI：10.1016/j.joca.2026.05.013delete
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Abstract

Abstract

En 中文
The clinical "bone-cartilage paradox" between osteoporosis (OP) and osteoarthritis (OA) remains controversial. Deciphering their causal link and underlying molecular switches is crucial for the integrated management of concurrent musculoskeletal diseases.
Keywords:
RSPO3
NFATC1
osteoporosis
osteoarthritis
bone-cartilage paradox

Journal

Osteoarthritis and Cartilage cover
Osteoarthritis and Cartilage
IF:
9
Papers:
1.3W
Citations:
2.2W

Organization

T
the third affiliated hospital of southern medical university
Scholars:
14
Papers: 7
Citations: 0
S
Shenzhen Bao'an District Songgang People's Hospital
Scholars:
5
Papers: 5
Citations: 0
Cited Papers

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Citing Papers

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