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Decoding Alzheimer's disease through down syndrome: insights from a genetically defined population
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DOI：10.1097/WCO.0000000000001461.png)
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Abstract
En 中文
This review explores Alzheimer's disease (AD) in individuals with Down syndrome (DS), a genetically defined population with near-universal development of AD neuropathology by age 40. We examine the genetic basis of DS–AD, epidemiology, biomarker trajectories, and clinical trial innovations, highlighting how insights from DS research inform broader AD pathogenesis, early detection, and therapeutic strategies.
Keywords:
Alzheimer's disease
biomarkers
dementia
down syndrome
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4.4
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