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Decoding and recoding plant development
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DOI：10.1093/plphys/kiab336.png)
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Abstract
En 中文
The development of multicellular organisms has been studied for centuries, yet many critical events and mechanisms of regulation remain challenging to observe directly. Early research focused on detailed observational and comparative studies. Molecular biology has generated insights into regulatory mechanisms, but only for a limited number of species. Now, synthetic biology is bringing these two approaches together, and by adding the possibility of sculpting novel morphologies, opening another path to understanding biology. Here, we review a variety of recently invented techniques that use CRISPR/Cas9 and phage integrases to trace the differentiation of cells over various timescales, as well as to decode the molecular states of cells in high spatiotemporal resolution. Most of these tools have been implemented in animals. The time is ripe for plant biologists to adopt and expand these approaches. Here, we describe how these tools could be used to monitor development in diverse plant species, as well as how they could guide efforts to recode programs of interest.
Keywords:
SITE-SPECIFIC RECOMBINATION
CLONAL ANALYSIS
CELL LINEAGES
ONCOGENE ACTIVATION
ARABIDOPSIS
SYSTEM
INFORMATION
EXPRESSION
MEMORY
TIME
Journal
IF:
6.9
Papers:
1.7W
Citations:
9.6W
Organization
Cited Papers
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NATURE CHEMICAL BIOLOGY
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NATURE CHEMICAL BIOLOGYIF13.7
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