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Decoding mosquito–virus interactions: from classical genetics to multi-omics
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DOI：10.1016/j.tim.2025.07.001.png)
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Abstract
En 中文
Harnessing the rich genetic diversity of wild mosquito populations has emerged as a powerful strategy for uncovering novel genetic determinants of vector competence. Targeted and unbiased approaches are complementary: unbiased methods can reveal novel candidate factors, which can subsequently be characterized in greater detail using hypothesis-driven targeted methods. Linkage mapping has clarified the genetic basis of vector competence, while multi-omics have deepened the understanding of mosquito–virus interactions. Single-cell and spatial omics offer unprecedented insights into mosquito infection dynamics and vector–virus interactions.
Keywords:
wild mosquito populations
vector competence
linkage mapping
multi-omics
single-cell omics