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Decreased Awareness of Cognitive Decline is Associated with Multimodal Alzheimer’s Disease Biomarkers in Cognitively Unimpaired Individuals
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DOI：10.1016/j.neurobiolaging.2026.06.006.png)
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Abstract
En 中文
• Defining a discrete clinical profile: decreased Awareness of Cognitive Decline (ACD) • Decline in episodic memory and cognitive awareness: subtle amnestic anosognosia Decreased ACD is linked to multimodal core Alzheimer’s disease (AD) biomarkers At the same threshold of memory decline, decreased ACD reflects greater AD pathology • Assessment of ACD provides a crucial extension of current AD clinical frameworks
Keywords:
Alzheimer’s disease
awareness of cognitive decline
episodic memory
anosognosia
multimodal biomarkers
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