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Deep learning as a generator of sodium channel state hypotheses

delete2026-03-10
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PRE
AI
S
Schmidt, Lisa
K
Kopec, Wojciech *
DOI：10.1085/jgp.202513938delete
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Abstract

Abstract

En 中文
Lopez-Mateos et al. show that AlphaFold 2 can generate structural ensembles of NaV channels and that beta-subunits and calmodulin reshape these ensembles, while emphasizing that these are testable structural hypotheses, not actual thermodynamic populations.

Journal

Journal of General Physiology cover
Journal of General Physiology
IF:
2.9
Papers:
3.3K
Citations:
7.2K

Organization

U
university of london
Scholars:
21.3W
Papers: 19.6W
Citations: 302
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