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Deep learning-enabled high-speed, multi-parameter diffuse optical tomography
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DOI：10.1117/1.JBO.29.7.076004.png)
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Abstract
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Significance Frequency-domain diffuse optical tomography (FD-DOT) could enhance clinical breast tumor characterization. However, conventional diffuse optical tomography (DOT) image reconstruction algorithms require case-by-case expert tuning and are too computationally intensive to provide feedback during a scan. Deep learning (DL) algorithms front-load computational and tuning costs, enabling high-speed, high-fidelity FD-DOT. Aim We aim to demonstrate a simultaneous reconstruction of three-dimensional absorption and reduced scattering coefficients using DL-FD-DOT, with a view toward real-time imaging with a handheld probe. Approach A DL model was trained to solve the DOT inverse problem using a realistically simulated FD-DOT dataset emulating a handheld probe for human breast imaging and tested using both synthetic and experimental data. Results Over a test set of 300 simulated tissue phantoms for absorption and scattering reconstructions, the DL-DOT model reduced the root mean square error by 12%+/- 40% and 23%+/- 40%, increased the spatial similarity by 17%+/- 17% and 9%+/- 15%, increased the anomaly contrast accuracy by 9%+/- 9% (mu a), and reduced the crosstalk by 5%+/- 18% and 7%+/- 11%, respectively, compared with model-based tomography. The average reconstruction time was reduced from 3.8 min to 0.02 s for a single reconstruction. The model was successfully verified using two tumor-emulating optical phantoms. Conclusions There is clinical potential for real-time functional imaging of human breast tissue using DL and FD-DOT.
Keywords:
deep learning
diffuse optical tomography
frequency domain
scattering
breast imaging
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