Defective m6A RNA Modification in Macrophages Exacerbates Inflammation and Promotes Colitis-Associated Carcinogenesis by Impairing Efferocytosis

2026-07-24

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Xueyan Song

Xiaohan Sa

Yuanshuai Zhou

Shaheryar Shafi

Danfeng Sun

Yuwen Han

Rongchuan Zhao

Qi Lu

Zekai Gong

Jianping Liu

Jinyu Yao

Jinlin Pan

Guohua Shi

Nan Ouyang

Shanze Chen

Jianqing Lin

Huang Xia

Nafees Ahmad

Sami Siraj

DOI：10.1016/j.canlet.2026.218761

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• METTL3-dependent m6A modification promotes macrophage efferocytosis under inflammatory stress. • Mettl3 deficiency impairs apoptotic cell clearance and aggravates chronic inflammatory injury. • METTL3 stabilizes MFGE8 mRNA through IGF2BP2/3-mediated post-transcriptional regulation. • Defective efferocytosis contributes to inflammation-associated colorectal carcinogenesis. • MFGE8 supplementation restores efferocytosis and reduces tumor burden in the AOM/DSS model.

Defective m6A RNA Modification in Macrophages Exacerbates Inflammation and Promotes Colitis-Associated Carcinogenesis by Impairing Efferocytosis

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