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Defining Healthy Weight Loss and Target Weight in the Era of Highly Effective Treatment of Patients With Obesity
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DOI：10.1002/jcsm.70334.png)
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Abstract
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Highly effective anti-obesity medications (AOMs) induce substantial weight loss and have renewed debate on appropriate treatment targets. Weight loss comprises reductions in fat mass (FM) and fat-free mass (FFM), with skeletal muscle (SM) as the major component of FFM. Clinical trials report that 20%–40% of total weight loss is attributable to FFM, raising concerns about excessive SM loss and sarcopenia risk.
Keywords:
anti-obesity medication
fat-free mass
fat mass
partitioning
skeletal muscle mass
weight loss
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