Defining Rapid Early Progression in Glioblastoma — A Volumetric Approach

Vikram Munlapudi, BS

doi:10.1093/noajnl/vdag153

Defining Rapid Early Progression in Glioblastoma — A Volumetric Approach

2026-06-08

0

OA

AI

V

Vikram Munlapudi, BS

J

Jacob Guzzino, BS

D

David J Crompton, MD

S

Shubhi Agarwal, MD

E

Eric J Lehrer, MD

S

Shelby Kern, PA-C, MS

A

Aaron Bogan, MA

S

Sujay A Vora, MD

A

Alfredo Quinones-Hinojosa, MD

T

Terry C Burns, MD, PhD

W

Wendy J Sherman, MD

P

Paul D Brown, MD

N

Nadia Laack, MD

J

Jennifer Peterson, MD

J

Joon H Uhm, MD

M

Michael W Ruff, MD

U

Ugur T Sener, MD

W

William G Breen, MD

D

Daniel M Trifiletti, MD *

DOI：10.1093/noajnl/vdag153

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Abstract

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The current treatment of glioblastoma involves resection followed by radiotherapy (RT) and temozolomide. Rapid early progression (REP) of tumor in the surgery-to-radiotherapy interval (SRI) has been described using categorical or semi-quantitative assessments and is associated with inferior clinical outcomes. This study seeks to establish and validate a quantitative definition for REP and examine how REP could inform future therapy.

Defining Rapid Early Progression in Glioblastoma — A Volumetric Approach

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