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DELs Inside Cells
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DOI：10.1016/j.tips.2020.01.007.png)
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Abstract
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DNA-encoded libraries (DELs) comprise large numbers of small molecules, each of which is conjugated to an encoding DNA. Krusemark and colleagues recently described a method to introduce DELs into living cells and recover conjugates that bind to an intracellular target. This proof-of-principle study suggests that it may be feasible to screen DELs against protein targets in their native environment.
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Design, synthesis and selection of DNA-encoded small-molecule libraries.png)
NATURE CHEMICAL BIOLOGY
NATURE CHEMICAL BIOLOGYIF13.7
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