.png){kind=icon}
.png){kind=icon}
Return
Demonstrating a Folding Strategy Utilizing Phosphine-Catalyzed Intramolecular Rauhut–Currier Reaction
.png){kind=icon}
PRE
AI
D
A
B
K
S
DOI：10.1002/adsc.70172.png)
.png){kind=icon}
Original request for help.png){kind=icon}
Share.png){kind=icon}
Save
Abstract
En 中文
A folding strategy of the diversity-oriented synthesis (DOS) utilizing nucleophilic organophosphine-promoted intramolecular Rauhut–Currier reaction is presented. Besides establishing a DOS variant, the strategy facilitates the rapid synthesis of highly substituted indanones and dibenzocycloheptanones under metal-free and neutral conditions. Phosphines efficiently catalyze the transformation of various tethered bis-enones, resulting in the formation of β-alkylated α-arylidene/allylidene indanones and dibenzocycloheptanones. These scaffolds are commonly found in numerous bioactive natural products and pharmaceutically relevant compounds. The broad applicability of the method across a wide range of substrates is demonstrated, and further enhances the skeletal and stereochemical diversity through several postsynthetic modifications.
Keywords:
dibenzocycloheptanes
folding strategy
indanes
organophosphines
Rauhut–Currier reaction
Journal
A
IF:
4
Papers:
1.0W
Citations:
2.6W
Organization
No organization information available
Cited Papers