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Deoxycholic acid ameliorates postmenopausal osteoporosis by rebalancing BMSC differentiation and suppressing NF-κB signaling
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DOI：10.1016/j.jnutbio.2026.110438.png)
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Abstract
En 中文
• Estrogen deficiency depletes gut microbiota-derived deoxycholic acid (DCA) in PMOP. • Mendelian Randomization identifies DCA as a causal protector of bone density. • DCA supplementation effectively mitigates OVX-induced trabecular bone loss in vivo. • DCA restores bone homeostasis by promoting BMSC osteoblastogenesis over adipogenesis. • DCA inhibits osteoclastogenesis by suppressing the IκB-α/NF-κB/NFATc1 signaling pathway.
Keywords:
Gut microbiota
Deoxycholic acid
Osteoporosis
Gut-bone axis
NF-κB signaling
Adipoq
,
adiponectin
Alp
,
alkaline phosphatase
Atgl
,
adipose triglyceride lipase
BA
,
bile acid
β-CTX
,
β-CrossLaps
BMD
,
bone mineral density
Bsep
,
bile salt export pump
Cebp
,
Ccaat/enhancer-binding protein
Col1a1
,
collagen type I alpha 1 chain
Ctsk
,
cathepsin K
Cyp27a1
,
cytochrome P450 family 27 subfamily A member 1
Cyp7a1
,
cytochrome P450 family 7 subfamily A member 1
Cyp8b1
,
cytochrome P450 family 8 subfamily B member 1
DCA
,
deoxycholic acid
FXR
,
farnesoid X receptor
Ikk
,
inhibitor of nuclear factor kappa B kinase
IκB-α
,
NF-kappa-B inhibitor alpha
Jam3
,
junctional adhesion molecule 3
LCA
,
lithocholic acid
Mgll
,
monoacylglycerol lipase
Mmp9
,
matrix metallopeptidase 9
Nfatc1
,
nuclear factor of activated T-cells 1
NF-κB
,
nuclear factor kappa B
Ntcp
,
Na+-taurocholate cotransporting polypeptide
P1NP
,
procollagen Type I N-terminal propeptide
Pparγ
,
peroxisome proliferator-activated receptor gamma
Runx2
,
runt-related transcription factor 2
TGR5
,
G protein-coupled bile acid receptor 1
Trap
,
tartrate-resistant acid phosphatase
Zo-1
,
zonula occludens-1
Journal
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Citations:
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